An oral presentation by Suzanne Trudel

An oral presentation by Suzanne Trudel, Assistant Professor, Pri These data were presented at the AACR Annual Meeting in a poster titled ‘SNS-032, a novel inhibitor of cyclin – dependent kinases 2, 7 and 9, the transcription of cyclin D1 and Mcl-1 cell death caused in mantle cell lymphoma cell lines ‘ .

CaviStat was developed and clinically tested by researchers at the Department of Oral Biology and Pathology at Stony Brook University School of Dental Medicine. The technology was patented and exclusively Ortek by the Research Foundation of the State University of New York through its campus arm, the Office of Technology Licensing & Industry Relations the body responsible for licensing SUNY technology licensed. Ortek is a successful local start-up company at Stony Brook University that OTLIR helped found. The company plans to submit an Investigational New Drug application with the U.S. Food and Drug Administration later this year. BasicMints currently not for use in the U.S. All of components are naturally CaviStat allowed in the human body. ‘Affect cavities of the quality of life for millions of children every year by repairing them to miss pain, school days and cost billions of dollars annually,’said Israel Kleinberg, the lead researcher and inventor of CaviStat technology and Distinguished Professor and Founding Director Chairman of the Department of Oral Biology and Pathology at SBU School of Dental Medicine. ‘This study shows for the first time that this new fluoride-free, cavity – fighting tool has the potential to significantly improve , the oral health of children. ‘.

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Preclinical studies in rats and dogs, LT – NS001 been shown to significantly less damaging the the gastrointestinal section as perform similar doses of naproxen. The study will be assessment gastrointestinal injury by endoscopy after 7 days of of treatment. LT – NS001 has previously randomized into two phase 1, placebo-controlled, twice – doses examined and multiple-dose pharmacokinetic studies. In all cases, LT – NS001. Moreover , when the subjects was metered twice a a day with a LT – NS001 the plasma concentrations with naproxen within the therapeutic range.