All the mice developed AAA at day 14.

All the mice developed AAA at day 14, but syndecan-1 knockout mice showed a significantly greater degree of dilation than wild-type mice (1.14 mm vs. 1, Histologic analysis revealed robust expression of syndecan-1 at the site AAA formation in wild-type mice. Gelatin zymography showed significantly higher levels of MMP-2 and MMP – 9 activity in syndecan-1 knockout mice 7 days (proMMP-9: 0.0069; proMMP-2: 0, A proteolytic activity was significantly higher in the Media knockout macrophages obtained as observed by wild-type controls.

According to Elliot L. Chaikof, Head of Vascular Surgery, vs. C57BL / 6 wild-type and 35 Syndecan-1 – knockout mice underwent transient elastase perfusion of the abdominal aorta to induce AAA. Aortic diameter was preperfusion, postperfusion and measured at harvest at 1, 7 and 14 days.Every year, there are about 1 million primary hip and knee joint in Europe, the number growing at present conducted by more than 4 % per year.